Guix

Recently, Guix gained cross-compilation support. What this means is that existing package definitions can be reused to cross compile packages. So for instance one can cross-compile Guile and its dependencies for MIPS with:

guix build --target=mips64el-linux-gnu guile 

This may sound like an unexpected feature for a "package manager". In fact, it is particularly useful when porting the GNU system distribution to new platforms. The distribution being self-contained, it is bootstrapped from a small set of pre-built binaries. With cross-compilation support, porting to a new platform boils down to cross-compiling the bootstrap binaries for that platform.