r-vsn 3.58.0 Variance stabilization and calibration for microarray data
The package implements a method for normalising microarray intensities, and works for single- and multiple-color arrays. It can also be used for data from other technologies, as long as they have similar format. The method uses a robust variant of the maximum-likelihood estimator for an additive-multiplicative error model and affine calibration. The model incorporates data calibration step (a.k.a. normalization), a model for the dependence of the variance on the mean intensity and a variance stabilizing data transformation. Differences between transformed intensities are analogous to "normalized log-ratios". However, in contrast to the latter, their variance is independent of the mean, and they are usually more sensitive and specific in detecting differential transcription.
- Website: https://bioconductor.org/packages/release/bioc/html/vsn.html
- License: Artistic License 2.0
- Package source: bioinformatics.scm
- Patches: None
- Builds: x86_64-linux, i686-linux, armhf-linux, aarch64-linux, i586-gnu